Left frontal connectivity attenuates the adverse effect of entorhinal tau pathology on memory.

ABSTRACT:

Objective

To investigate whether higher global left frontal cortex (gLFC) connectivity, a putative neural substrate of cognitive reserve, attenuates the effect of entorhinal tau PET levels on episodic memory in older adults.

Methods

Cross-sectional ¹⁸F-AV-1451 PET (to assess tau pathology), ¹⁸F-AV-45 or ¹⁸F-BAY94-9172 PET (to assess β-amyloid [Aβ]), and resting-state fMRI were obtained in 125 elderly participants from the Alzheimer's Neuroimaging Initiative, including 82 cognitively normal participants (amyloid PET-positive [Aβ+], n = 27) and 43 patients with amnestic mild cognitive impairment (Aβ+ = 15). Resting-state fMRI gLFC connectivity was computed for each participant as the average functional connectivity between the left frontal cort

SUBMITTER: Neitzel J 

PROVIDER: S-EPMC6669934 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature