Metabolic Adaptation in Methicillin-Resistant Staphylococcus aureus Pneumonia.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) is a versatile human pathogen that is associated with diverse types of infections ranging from benign colonization to sepsis. We postulated that MRSA must undergo specific genotypic and phenotypic changes to cause chronic pulmonary disease. We investigated how MRSA adapts to the human airway to establish chronic infection, as occurs during cystic fibrosis (CF). MRSA isolates from patients with CF that were collected over a 4-year period were analyzed by whole-genome sequencing, transcriptional analysis, and metabolic studies. Persistent MRSA infection was associated with staphylococcal metabolic adaptation, but not changes in immunogenicity. Adaptation was characterized by selective use of the tricarboxylic acid cycle cycle and gene

SUBMITTER: Gabryszewski SJ 

PROVIDER: S-EPMC6670030 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature