Changes in microparticle profiles by vitamin D receptor activation in chronic kidney disease - a randomized trial.

ABSTRACT:

Background

Microparticles (MPs) are biomarkers and mediators of disease through their expression of surface receptors, reflecting activation or stress in their parent cells. Endothelial markers, ICAM-1 and VCAM-1, are implicated in atherosclerosis and associated with cardiovascular risk. Chronic kidney disease (CKD) patients have endothelial dysfunction and high levels of endothelial derived MPs. Vitamin D treatment has been reported to ameliorate endothelial function in CKD patients. We aimed to examine cell specific MP profiles and concentrations of MPs expressing the atherosclerotic markers ICAM-1 and VCAM-1 after treatment with paricalcitol in patients with CKD stage 3-4.

Methods

Sub-study of the previously reported SOLID trial where 36 patients were randomly assigned to

SUBMITTER: Lundwall K 

PROVIDER: S-EPMC6670162 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature