Proteomic and histopathological characterisation of sicca subjects and primary Sjogren's syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers.

ABSTRACT:

Background

Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren's syndrome (pSS). Non-SS sicca subjects, an underexplored group in relation to pSS, display similar sicca symptoms, with possible mild signs of inflammation in their salivary glands, yet with no serological detection of autoantibody production. In this study, we investigated inflammatory manifestations in the salivary gland tissue, tear fluid and saliva of non-SS subjects, as compared to pSS patients and healthy individuals.

Methods

Fifteen non-SS, 10 pSS and 10 healthy subjects were included in the analyses. Histological evaluation of salivary gland biopsies was performed. Liquid chrom

SUBMITTER: Aqrawi LA 

PROVIDER: S-EPMC6670195 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature