Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers.

ABSTRACT:

Background

Claudin-low breast cancer is a molecular subtype associated with poor prognosis and without targeted treatment options. The claudin-low subtype is defined by certain biological characteristics, some of which may be clinically actionable, such as high immunogenicity. In mice, the medroxyprogesterone acetate (MPA) and 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumor model yields a heterogeneous set of tumors, a subset of which display claudin-low features. Neither the genomic characteristics of MPA/DMBA-induced claudin-low tumors nor those of human claudin-low breast tumors have been thoroughly explored.

Methods

The transcriptomic characteristics and subtypes of MPA/DMBA-induced mouse mammary tumors were determined using gene expression microarrays. Somatic

SUBMITTER: Fougner C 

PROVIDER: S-EPMC6670237 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature