NPY₂ Receptors Reduce Tonic Action Potential-Independent GABA_B Currents in the Basolateral Amygdala.

ABSTRACT: Although NPY has potent anxiolytic actions within the BLA, selective activation of BLA NPY Y₂ receptors (Y₂Rs) acutely increases anxiety by an unknown mechanism. Using ex vivo male rat brain slice electrophysiology, we show that the selective Y₂R agonist, [ahx^5-24]NPY, reduced the frequency of GABA_A-mediated mIPSCs in BLA principal neurons (PNs). [ahx^5-24]NPY also reduced tonic activation of GABA_B receptors (GABA_BR), which increased PN excitability through inhibition of a tonic, inwardly rectifying potassium current (K_IR ). Surprisingly, Y₂R-sensitive GABA_BR currents were action potential-independent, persisting after treatment with TTX. Additionally, the C

SUBMITTER: Mackay JP 

PROVIDER: S-EPMC6670257 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature