Evaluation of NCI-7 Cell Line Panel as a Reference Material for Clinical Proteomics.

ABSTRACT: Reference materials are vital to benchmarking the reproducibility of clinical tests and essential for monitoring laboratory performance for clinical proteomics. The reference material utilized for mass spectrometric analysis of the human proteome would ideally contain enough proteins to be suitably representative of the human proteome, as well as exhibit a stable protein composition in different batches of sample regeneration. Previously, The Clinical Proteomic Tumor Analysis Consortium (CPTAC) utilized a PDX-derived comparative reference (CompRef) materials for the longitudinal assessment of proteomic performance; however, inherent drawbacks of PDX-derived material, including extended time needed to grow tumors and high level of expertise needed, have resulted in efforts to identify a new

SUBMITTER: Clark DJ 

PROVIDER: S-EPMC6670293 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature