P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury.

ABSTRACT: Extracellular nucleotides have been implicated as signaling molecules used by microglia to sense adverse physiological conditions, such as neuronal damage. They act through purinoceptors, especially the G-protein-coupled P2Y receptor P2Y(12)R. Emerging evidence has indicated that activated spinal microglia responding to nerve injury are key cellular intermediaries in the resulting highly debilitating chronic pain state, namely neuropathic pain. However, the role of microglial P2Y(12)Rs in neuropathic pain remains unknown. Here, we show that the level of P2Y(12)R mRNA expression was markedly increased in the spinal cord ipsilateral to the nerve injury and that this expression was highly restricted to ionized binding calcium adapter molecule 1-positive microglia. An increase in the immunoflu

SUBMITTER: Tozaki-Saitoh H 

PROVIDER: S-EPMC6670742 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature