Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease.

ABSTRACT: Alpha-synuclein (alpha-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease. These disorders are characterized by various neurological and psychiatric symptoms based on progressive neuropathological alterations. Whether the neurodegenerative process might be halted or even reversed is presently unknown. Therefore, conditional mouse models are powerful tools to analyze the relationship between transgene expression and progression of the disease. To explore whether alpha-syn solely originates and further incites these alterations, we generated conditional mouse models by using the tet-regulatable system. Mice expressing high levels of human wild-type alpha-syn in midbrain and forebrain regions developed nigral and hippocampal neuropa

SUBMITTER: Nuber S 

PROVIDER: S-EPMC6671187 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature