Expression of nonclassical class I major histocompatibility genes defines a tripartite organization of the mouse vomeronasal system.

ABSTRACT: The epithelium of the mouse vomeronasal organ (VNO) consists of apical and basal layers of neuronal cell bodies. Vomeronasal sensory neurons (VSNs) with cell bodies in the basal layer express the G-protein subunit G alpha(o) and members of the V2R superfamily of vomeronasal receptor genes and project their axons to the posterior accessory bulb (AOB). V2R(+) VSNs also express particular patterns of a family of nine nonclassical class I major histocompatibility Mhc genes, the H2-Mv genes. The function of H2-Mv molecules remains unknown. H2-Mv molecules have been reported to be associated with V2R molecules and have been proposed to participate in pheromone detection. Here, we find that a substantial fraction of V2R(+) VSNs does not express these nine H2-Mv genes. The cell bodies of H2-Mv(+)

SUBMITTER: Ishii T 

PROVIDER: S-EPMC6671199 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature