Lipoprotein Lipase Up-regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice.

ABSTRACT: Lipoprotein lipase (LPL) plays a central role in incorporating plasma lipids into tissues and regulates lipid metabolism and energy balance in the human body. Conversely, LPL expression is almost absent in normal adult livers. Therefore, its physiological role in the liver remains unknown. We aimed to elucidate the role of LPL in the pathophysiology of nonalcoholic steatohepatitis (NASH), a hepatic manifestation of obesity. Hepatic stellate cell (HSC)-specific LPL-knockout (Lpl^HSC-KO ) mice, LPL-floxed (Lpl^fl/fl ) mice, or double-mutant toll-like receptor 4-deficient (Tlr4^-/- ) Lpl^HSC-KO mice were fed a high-fat/high-cholesterol diet for 4 weeks to establish the nonalcoholic fatty liver model or an high-fat/high-choles

SUBMITTER: Teratani T 

PROVIDER: S-EPMC6671781 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature