The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system.

ABSTRACT: Effective management of brain and spine tumors relies on a multidisciplinary approach encompassing surgery, radiation, and systemic therapy. In the era of personalized oncology, the latter is complemented by various molecularly targeting agents. Precise identification of cellular targets for these drugs requires comprehensive profiling of the cancer genome coupled with an efficient analytic pipeline, leading to an informed decision on drug selection, prognosis, and confirmation of the original pathological diagnosis. Acquisition of optimal tumor tissue for such analysis is paramount and often presents logistical challenges in neurosurgery. Here, we describe the experience and results of the Personalized OncoGenomics (POG) program with a focus on tumors of the central nervous system (CNS).

SUBMITTER: Wong D 

PROVIDER: S-EPMC6672021 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature