Effects of Alzheimer's disease on different cortical layers: the role of intrinsic differences in Abeta susceptibility.

ABSTRACT: Alzheimer's disease is late life dementia associated with significant neurodegeneration in both cortical and subcortical regions. During the approximately 10 year course of the disease, neurons are lost in a progressive pattern that is relatively consistent among individuals. One example of this is the progression of disease pathology found in both the neocortex and archicortex. In these structures, the earliest problems can be found in superficial cortical layers (II-IV), whereas later the disease advances to involve the deeper cortical layers (V-VI). It is unclear whether these apparent differences in sensitivity are intrinsic to the neurons or imposed by external factors such as the pattern of connections. We used beta-amyloid (Abeta) peptide treatment of cultured mouse neurons as our m

SUBMITTER: Romito-DiGiacomo RR 

PROVIDER: S-EPMC6672937 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature