The heat shock response and chaperones/heat shock proteins in brain tumors: surface expression, release, and possible immune consequences.

ABSTRACT: The heat shock response is a highly conserved "stress response" mechanism used by cells to protect themselves from potentially damaging insults. It often involves the upregulated expression of chaperone and heat shock proteins (HSPs) to prevent damage and aggregation at the proteome level. Like most cancers, brain tumor cells often overexpress chaperones/HSPs, probably because of the stressful atmosphere in which tumors reside, but also because of the benefits of HSP cytoprotection. However, the cellular dynamics and localization of HSPs in either stressed or unstressed conditions has not been studied extensively in brain tumor cells. We have examined the changes in HSP expression and in cell surface/extracellular localization of selected brain tumor cell lines under heat shock or normal e

SUBMITTER: Graner MW 

PROVIDER: S-EPMC6673020 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature