TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons.

ABSTRACT: The ability of neurons, such as cerebellar granule neurons (CGNs), to fire action potentials (APs) at high frequencies during sustained depolarization is usually explained in relation to the functional properties of voltage-gated ion channels. Two-pore domain potassium (K(2P)) channels are considered to simply hyperpolarize the resting membrane potential (RMP) by increasing the potassium permeability of the membrane. However, we find that CGNs lacking the TASK-3 type K(2P) channel exhibit marked accommodation of action potential firing. The accommodation phenotype was not associated with any change in the functional properties of the underlying voltage-gated sodium channels, nor could it be explained by the more depolarized RMP that resulted from TASK-3 channel deletion. A functional rescu

SUBMITTER: Brickley SG 

PROVIDER: S-EPMC6673138 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature