The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.

ABSTRACT: The ventromedial hypothalamus (VMH) is a distinct morphological nucleus involved in feeding, fear, thermoregulation, and sexual activity. It is essentially unknown how VMH circuits underlying these innate responses develop, in part because the VMH remains poorly defined at a cellular and molecular level. Specifically, there is a paucity of cell-type-specific genetic markers with which to identify neuronal subgroups and manipulate development and signaling in vivo. Using gene profiling, we now identify approximately 200 genes highly enriched in neonatal (postnatal day 0) mouse VMH tissue. Analyses of these VMH markers by real or virtual (Allen Brain Atlas; http://www.brain-map.org) experiments revealed distinct regional patterning within the newly formed VMH. Top neonatal markers include tr

SUBMITTER: Kurrasch DM 

PROVIDER: S-EPMC6673626 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature