Prospects for pharmacotherapies to treat alcohol use disorder: an update on recent human studies.

ABSTRACT:

Purpose of review

The aim of this study was to provide an update on medication development efforts for alcohol use disorder (AUD) by reviewing recently published (past 2 years) human studies that evaluated medications' effects on alcohol-related outcomes.

Recent findings

Forty-five publications were found suitable for this review. A variety of compounds have been tested in the past 2 years as potential pharmacological options for AUD, including medications that act on multiple targets (topiramate, aripiprazole, quetiapine), calcium channels (gabapentin), gamma-Aminobutyric acid receptors (baclofen, diazepam), glutamate receptors (ifenprodil, memantine, glycine), nicotinic acetylcholine receptors (varenicline, mecamylamine), α1 adrenergic receptors (prazosin, doxazosin), neur

SUBMITTER: Farokhnia M 

PROVIDER: S-EPMC6673672 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature