Inverted-U profile of dopamine-NMDA-mediated spontaneous avalanche recurrence in superficial layers of rat prefrontal cortex.

ABSTRACT: Prefrontal cortex (PFC) functions, such as working memory, attention selection, and memory retrieval, depend critically on dopamine and NMDA receptor activation by way of an inverted-U-shaped pharmacological profile. Although single neuron responses in the PFC have shown some aspects of this profile, a network dynamic that follows the dopamine-NMDA dependence has not been identified. We studied neuronal network activity in acute medial PFC slices of adult rats by recording local field potentials (LFPs) with microelectrode arrays. Bath application of dopamine or the dopamine D1 agonist SKF38393 [(+/-)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride] in combination with NMDA induced spontaneous LFPs predominantly in superficial cortex layers. The LFPs at single electrod

SUBMITTER: Stewart CV 

PROVIDER: S-EPMC6673780 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature