Hippocampal lesion prevents spatial relational learning in adult macaque monkeys.

ABSTRACT: The role of the hippocampus in spatial learning and memory has been extensively studied in rodents. Comparable studies in nonhuman primates, however, are few, and findings are often contradictory. This may be attributable to the failure to distinguish between allocentric and egocentric spatial representations in experimental designs. For this experiment, six adult monkeys received bilateral hippocampal ibotenic acid lesions, and six control subjects underwent sham surgery. Freely moving monkeys then foraged for food located in two arrays of three distinct locations among 18 locations distributed in an open-field arena. Multiple goals and four pseudorandomly chosen entrance points precluded the monkeys' ability to rely on an egocentric strategy to identify food locations. Monkeys were teste

SUBMITTER: Lavenex PB 

PROVIDER: S-EPMC6674053 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature