Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex.

ABSTRACT: The entorhinal cortex (EC) is a significant component of the systems that underlie certain forms of memory formation and recall. Evidence has been emerging that the dopaminergic system in the EC facilitates these and other functions of the EC. The effects of dopamine (DA) on membrane properties and excitability of EC neurons, however, are not known. We used in vitro whole-cell patch-clamp recordings from layer V pyramidal neuronal somata and dendrites of the adult rat lateral EC to investigate the effects of DA on the excitability of these neurons. We found that brief application of DA caused a reduction in the excitability of layer V EC pyramidal neurons. This effect was attributable to voltage-dependent modification of membrane properties that can best be explained by an increase in a hy

SUBMITTER: Rosenkranz JA 

PROVIDER: S-EPMC6674109 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature