Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity.

ABSTRACT: Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affects the brain function of offspring when they are adult remains primarily unknown. In the present work, chronic immobilization stress to pregnant mice affected fetal growth and development. When pups born from stressed mice were reared to adulthood in an environment identical to that of nonstressed controls, several physiological parameters were essentially unaltered. However, spatial learning and memory was significantly impaired in the maternally stressed offspring in adulthood. Furthermore, electrophysiological examination revealed a significant reduction in NMDA receptor-mediated long-term potentiation in the CA1 area of hippocampal slices. Subsequent biochem

SUBMITTER: Son GH 

PROVIDER: S-EPMC6674110 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature