Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids.

ABSTRACT: BACKGROUND:Overweight/obesity (OW) is linked to worse asthma and poorer inhaled corticosteroid (ICS) response in older children and adults. OBJECTIVE:We sought to describe the relationships between OW and asthma severity and response to ICS in preschool children. METHODS:This post hoc study of 3 large multicenter trials involving 2- to 5-year-old children compared annualized asthma symptom days and exacerbations among normal weight (NW) (body mass index: 10th-84th percentiles) versus OW (body mass index: ≥85th percentile) participants. Participants had been randomized to daily ICS, intermittent ICS, or daily placebo. Simple and multivariable linear regression was used to compare body mass index groups. RESULTS:Within the group not treated with a daily controller, OW children had more asthm

SUBMITTER: Lang JE 

PROVIDER: S-EPMC6675020 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature