Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods.

ABSTRACT:

Background

Preventive chemotherapy (PC) with benzimidazole drugs is the backbone of soil-transmitted helminth (STH) control programs. Over the past decade, drug coverage has increased and with it, the possibility of developing anthelmintic resistance. It is therefore of utmost importance to monitor drug efficacy. Currently, a variety of novel diagnostic methods are available, but it remains unclear whether they can be used to monitor drug efficacy. In this study, we compared the efficacy of albendazole (ALB) measured by different diagnostic methods in a head-to-head comparison to the recommended single Kato-Katz.

Methods

An ALB efficacy trial was performed in 3 different STH-endemic countries (Ethiopia, Lao PDR and Tanzania), each with a different PC-history. During these tr

SUBMITTER: Vlaminck J 

PROVIDER: S-EPMC6675043 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature