Endometriosis accelerates synchronization of early embryo cell divisions but does not change morphokinetic dynamics in endometriosis patients.

ABSTRACT:

Objective

The pathology of endometriosis and its impact on embryo development is still a black box in reproductive medicine. In this time-lapse study we investigated the influence of endometriosis on morphokinetic parameters of embryo development, taking variables of dynamic monitoring into account. Furthermore we evaluated reproductive medicine treatment outcome such as fetal heartbeat and live birth rate.

Methods

1148 embryos (control: n = 596, endometriosis: n = 552) were retrospectively analyzed. Patients were stimulated with GnRH antagonist protocol. After fertilization, embryos were incubated in a time-lapse system (EmbryoScope).

Results

The mixed-model analysis revealed a significant main effect of time (p<0.001), with post-hoc tests showing that any time neede

SUBMITTER: Schenk M 

PROVIDER: S-EPMC6675061 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature