Unveil the transcriptional landscape at the Cryptococcus-host axis in mice and nonhuman primates.

ABSTRACT: Pathogens and hosts require rapid modulation of virulence and defense mechanisms at the infection axis, but monitoring such modulations is challenging. In studying the human fungal pathogen Cryptococcus neoformans, mouse and rabbit infection models are often employed to shed light on the disease mechanisms but that may not be clinically relevant. In this study, we developed an animal infection model using the non-human primate cynomolgus monkey Macaca fascicularis. In addition, we systematically profiled and compared transcriptional responses between the infected mice and the cynomolgus monkey, using simultaneous or dual RNA next-generation sequencing. We demonstrated that there are shared but distinct transcriptional profiles between the two models following C. neoformans infection. Speci

SUBMITTER: Li H 

PROVIDER: S-EPMC6675133 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature