A novel pressor area at the medullo-cervical junction that is not dependent on the RVLM: efferent pathways and chemical mediators.

ABSTRACT: Chemical stimulation of a region extending from the most caudal ventrolateral medulla into the upper cervical spinal cord evoked large sympathetically mediated pressor responses. These responses were not dependent on the integrity of the rostral ventrolateral medulla (RVLM) and may be mediated by glutamatergic neurons embedded in the white matter that project to the thoracic spinal cord. We term this new region the medullo-cervical pressor area (MCPA). This region is distinct from the caudal pressor area, because blockade of the RVLM with muscimol inhibited this pressor response but not that evoked from the MCPA. This is the first study to provide functional evidence for a cardiovascular role for neurons in the cervical spinal cord white matter that innervate sympathetic preganglionic neur

SUBMITTER: Seyedabadi M 

PROVIDER: S-EPMC6675303 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature