Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration.

ABSTRACT: Owing to excellent therapeutic potential, mesenchymal stem cells (MSCs) are gaining increasing popularity with researchers worldwide for applications in tissue engineering, and in treatment of inflammation-related and age-related disorders. However, the senescence of MSCs over passaging has limited their clinical application owing to adverse effect on physiological function maintenance of tissues as well as disease treatment. An inflammatory microenvironment is one of the key contributors to MSC senescence, resulting in low regeneration efficiency. Therefore, MSCs with high resistance to cellular senescence would be a benefit for tissue regeneration. Toward this end, we analyzed the senescence properties of different types of stem cells during culture and under inflammation, including dent

SUBMITTER: Ma L 

PROVIDER: S-EPMC6675537 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature