Quality of life in pediatric acute myeloid leukemia: Report from the Children's Oncology Group.

ABSTRACT:

Introduction

Objectives were used to describe guardian proxy-report and child self-report quality of life (QoL) during chemotherapy for pediatric acute myeloid leukemia (AML) patients.

Methods

Patients enrolled on the phase 3 AML trial AAML1031 who were 2-18 years of age with English-speaking guardians were eligible. Instruments used were the PedsQL Generic Core Scales, Acute Cancer Module, and Multidimensional Fatigue Scale. Assessments were obtained at the beginning of Induction 1 and following completion of cycles 2-4. Potential predictors of QoL included the total number of nonhematological grade 3-4 Common Terminology Criteria for Adverse Event (CTCAE) submissions.

Results

There were 505 eligible guardians who consented to participate and 348 of their children pr

SUBMITTER: Nagarajan R 

PROVIDER: S-EPMC6675729 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature