Prognostic significance of GAD1 overexpression in patients with resected lung adenocarcinoma.

ABSTRACT:

Background and objectives

In a previous genome-wide screening, we identified hypermethylated CpG islands around glutamate decarboxylase 1 (GAD1) in lung adenocarcinoma (LADC). In this study, we aimed to investigate the methylation and expression status of GAD1 and its prognostic value in patients with LADC.

Methods

GAD1 methylation and mRNA expression status were analyzed using 33 tumorous and paired non-tumorous LADC samples and publicly available datasets. The prognostic value of GAD1 overexpression was investigated using publicly available datasets of mRNA levels and 162 cases of LADC by immunohistochemistry.

Results

The methylation and mRNA expression levels of GAD1, each having a positive correlation, were significantly higher in LADC tumors than in paired non-tu

SUBMITTER: Tsuboi M 

PROVIDER: S-EPMC6675743 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature