Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs.

ABSTRACT:

Background

Osteoarthritis (OA) is a highly prevalent degenerative joint disease involving joint cartilage and its surrounding tissues. OA is the leading cause of pain and disability worldwide. At present, there are no disease-modifying OA drugs, and the primary therapies include exercise and nonsteroidal anti-inflammatory drugs until total joint replacement at the end-stage of the disease.

Methods

In this review, we summarized the current state of knowledge in genetic and epigenetic associations and risk factors for OA and their potential diagnostic and therapeutic applications.

Results

Genome-wide association studies and analysis of epigenetic modifications (such as miRNA expression, DNA methylation and histone modifications) conducted across various populations supp

SUBMITTER: Choi YR 

PROVIDER: S-EPMC6675820 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature