Remote ischaemic preconditioning does not modulate the systemic inflammatory response or renal tubular stress biomarkers after endotoxaemia in healthy human volunteers: a single-centre, mechanistic, randomised controlled trial.

ABSTRACT:

Background

Remote ischaemic preconditioning (RIPC) consists of repeated cycles of limb ischaemia and reperfusion, which may reduce perioperative myocardial ischaemic damage and kidney injury. We hypothesised that RIPC may be beneficial by attenuating the systemic inflammatory response. We investigated whether RIPC affects the response in humans to bacterial endotoxin (lipopolysaccharide [LPS]) by measuring plasma cytokines and renal cell-cycle arrest mediators, which reflect renal tubular stress.

Methods

Healthy male volunteers were randomised to receive either daily RIPC for 6 consecutive days (RIPC_multiple, n=10) plus RIPC during the 40 min preceding i.v. LPS (2 ng kg^-1), RIPC only during the 40 min before LPS (RIPC_single, n=10), or no RIPC

SUBMITTER: Zwaag J 

PROVIDER: S-EPMC6676055 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature