DNA methylation changes involved in the tumor increase in F2 males born to gestationally arsenite-exposed F1 male mice.

ABSTRACT: Multigenerational adverse effects from the environment such as nutrition and chemicals are among important concerns in environmental health issues. Previously, we have found that arsenite exposure of only F0 females during their pregnancy increases hepatic tumors in the F2 males in C3H mice. In the current study, we investigated the association of DNA methylation with the hepatic tumor increase in the F2 males of the arsenite group. Reduced-representation bisulfite sequencing analysis newly identified that DNA methylation levels of regions around the transcriptional start sites of Tmem54 and Cd74 were decreased and the expression of these genes were significantly increased in the hepatic tumors of F2 males of the arsenite group. The associations between DNA methylation in these regions and

SUBMITTER: Okamura K 

PROVIDER: S-EPMC6676110 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature