Oral administration of Urtica macrorrhiza Hand.-Mazz. polysaccharides to protect against cyclophosphamide-induced intestinal immunosuppression.

ABSTRACT: As a strategy to prevent the well-known immunosuppressant effects of cyclophosphamide (CY), the immunomodulatory activity of the polysaccharide isolated from Urtica macrorrhiza Hand.-Mazz. (UMHMPS) was investigated in the present study. The chemical properties of UMHMPS, including total carbohydrates, uronic acid, protein contents, monosaccharide compositions, molecular weight and structural confirmation, were investigated. The immunomodulatory activity of UMHMPS was evaluated using a CY-induced immunosuppression mouse model. The results revealed that UMHMPS, which is composed of rhamnose, gluconic acid, galactose acid, galactose and xylose, exhibited potent immunomodulatory activity and low toxicity in mice. It increased the secretions of secretory immunoglobulin A, interferon (IFN

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6676156 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature