The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population.

ABSTRACT:

Aims

We aimed to investigate whether metabolomic profiling of blood can lead to novel insights into heart failure pathogenesis or improved risk prediction.

Methods and results

Mass spectrometry-based metabolomic profiling was performed in plasma or serum samples from three community-based cohorts without heart failure at baseline (total n = 3924; 341 incident heart failure events; median follow-up ranging from 4.6 to 13.9 years). Cox proportional hazard models were applied to assess the association of each of the 206 identified metabolites with incident heart failure in the discovery cohorts Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) (n = 920) and Uppsala Longitudinal Study of Adult Men (ULSAM) (n = 1121). Replication was undertaken in the indepe

SUBMITTER: Stenemo M 

PROVIDER: S-EPMC6676274 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature