Identifying a low-flow phenotype in heart failure with preserved ejection fraction: a secondary analysis of the RELAX trial.

ABSTRACT:

Aims

The relationship between resting stroke volume (SV) and prognostic markers in heart failure with preserved ejection fraction (HFpEF) is not well established. We evaluated the association of SV index (SVI) at rest with exercise capacity and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in stable patients with HFpEF.

Methods and results

Participants enrolled in the Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure (RELAX) trial with available data on SVI by the Doppler method were included in this analysis (n = 185). A low-flow state defined by resting SVI < 35 mL/m² was present in 37% of study participants. Multivariable adjusted linear regression analysis suggested that higher resting heart rate

SUBMITTER: Patel KV 

PROVIDER: S-EPMC6676300 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature