High vs. low oxygen therapy in patients with acute heart failure: HiLo-HF pilot trial.

ABSTRACT:

Aims

Most patients with acute heart failure (AHF) are treated with supplemental oxygen during hospitalization. In this study, we investigated the effect of oxygen titrated to high vs. low pulse oximetry targets in patients hospitalized with AHF.

Methods and results

In a pilot, open-label randomized controlled trial (RCT), 50 patients who were admitted with AHF were randomized to either high (≥96%) or low (90-92%) SpO₂ targets. Oxygen was manually titrated to the assigned target ranges for 72 h. The primary endpoint was the change in N-terminal pro-brain-type natriuretic peptide (NT-proBNP) from randomization to 72 h, and secondary endpoints included patient-reported dyspnoea by visual analogue scale (VAS), patient global assessment (PGA), peak expiratory flow (PEF

SUBMITTER: Sepehrvand N 

PROVIDER: S-EPMC6676301 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature