Brain Peak Width of Skeletonized Mean Diffusivity (PSMD) and Cognitive Function in Later Life.

ABSTRACT: It is suggested that the brain's peak width of skeletonized water mean diffusivity (PSMD) is a neuro-biomarker of processing speed, an important aspect of cognitive aging. We tested whether PSMD is more strongly correlated with processing speed than with other cognitive domains, and more strongly than other structural brain MRI indices. Participants were 731 Lothian Birth Cohort 1936 members, mean age = 73 years (SD = 0.7); analytical sample was 656-680. Cognitive domains tested were as follows: processing speed (5 tests), visuospatial (3), memory (3), and verbal (3). Brain-imaging variables included PSMD, white matter diffusion parameters, hyperintensity volumes, gray and white matter volumes, and perivascular spaces. PSMD was significantly associated with processing speed (-0.27), visuos

SUBMITTER: Deary IJ 

PROVIDER: S-EPMC6676305 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature