Identification and characterization of biomarkers and their functions for docetaxel-resistant prostate cancer cells.

ABSTRACT: Docetaxel treatment is a standard chemotherapy strategy for castration-resistant prostate cancer (CRPC), and patients with CRPC eventually develop resistance to treatment. However, little is understood regarding the underlying mechanism of resistance. The present study aimed to identify the underlying crucial genes and regulatory networks associated with docetaxel resistance in prostate cancer using bioinformatics analyses. For this purpose, one expression profile dataset (GSE33455), which included two docetaxel-sensitive and two docetaxel-resistant cell lines, was downloaded from the Gene Expression Omnibus database, and analyses of differential gene expression and function enrichment were performed. A protein-protein interaction (PPI) network was constructed, and the associated hub genes

SUBMITTER: Deng L 

PROVIDER: S-EPMC6676406 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature