Baseline microbiota composition modulates antibiotic-mediated effects on the gut microbiota and host.

ABSTRACT:

Background

Normal mammalian development and homeostasis are dependent upon the gut microbiota. Antibiotics, essential for the treatment and prophylaxis of bacterial infections, can have collateral effects on the gut microbiota composition, which can in turn have far-reaching and potentially deleterious consequences for the host. However, the magnitude and duration of such collateral effects appear to vary between individuals. Furthermore, the degree to which such perturbations affect the host response is currently unclear. We aimed to test the hypothesis that different human microbiomes have different responses to a commonly prescribed antibiotic and that these differences may impact the host response.

Methods

Germ-free mice (n = 30) humanized with the microbiota of two unre

SUBMITTER: Lavelle A 

PROVIDER: S-EPMC6676565 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature