Comparative effectiveness of primary tumor resection in patients with stage III pancreatic adenocarcinoma.

ABSTRACT:

Background

Previous studies comparing primary tumor resection (PTR) to palliative treatment for advanced-stage pancreatic ductal adenocarcinoma (PDA) were limited by strong selection bias. We used multiple methods to control for confounding and selection bias to estimate the effect of PTR on survival for late-stage PDA.

Methods

Surveillance, Epidemiology, and End Results (SEER) 18 registry database for 2004 through 2014 was retrieved for the present study. A total of 4322 patients with stage III (AJCC, 6th) PDA were included in this study. Propensity score matching (PSM) was performed to eliminate possible bias. In addition, instrumental variable (IV) analysis was utilized to adjust for both measured and unmeasured confounders.

Results

A total of 4322 patients with st

SUBMITTER: Sun K 

PROVIDER: S-EPMC6676580 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature