Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer.

ABSTRACT:

Background

Mesenchymal stem cells (MSCs) are multipotent cells with broad immunosuppressive capacities. Recently, it has been reported that MSCs can transfer mitochondria to various cell types, including fibroblast, cancer, and endothelial cells. It has been suggested that mitochondrial transfer is associated with a physiological response to cues released by damaged cells to restore and regenerate damaged tissue. However, the role of mitochondrial transfer to immune competent cells has been poorly investigated.

Methods and results

Here, we analyzed the capacity of MSCs from the bone marrow (BM) of healthy donors (BM-MSCs) to transfer mitochondria to primary CD4⁺CCR6⁺CD45RO⁺ T helper 17 (Th17) cells by confocal microscopy and fluorescent-activ

SUBMITTER: Luz-Crawford P 

PROVIDER: S-EPMC6676586 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature