Uric Acid Has Different Effects on Spontaneous Brain Activities of Males and Females: A Cross-Sectional Resting-State Functional MR Imaging Study.

ABSTRACT:

Objective

To explore the relationship among serum uric acid (SUA) levels in different states of disease, human cognition, and spontaneous brain activities by resting-state functional MRI (rs-fMRI).

Methods

We prospectively recruited 100 subjects (age 58 ± 11 years, 55 females) who underwent fasting blood sampling, cognitive tests and rs-fMRI scans. The subjects were divided into two groups by sex and each sex group was further stratified into three subgroups according to SUA level in different states of disease. The amplitude of low-frequency fluctuation (ALFF) method was applied to assess spontaneous brain activity among groups. Pearson's correlation analysis was used to investigate the relationships between the mean ALFF values (mALFF) and cognitive tests.

Results

A

SUBMITTER: Lin L 

PROVIDER: S-EPMC6676594 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature