Expression patterns of programmed death-1 and programmed death-1 ligand-1 on T cells in gastric cancer.

ABSTRACT: The aim of the present study was to evaluate programmed death-1 (PD-1) and programmed death-1 ligand-1 (PD-L1) expression in gastric carcinoma and to assess their effect on survival rate. A total of 170 surgically resected specimens were obtained from patients diagnosed with gastric carcinoma at St. Vincents Hospital, The Catholic University of Korea. Paraffin tissue sections from tissue microarray blocks were subjected to immunohistochemical analysis of PD-1 and PD-L1. In addition, PD-1 expression on CD4⁺ and CD8⁺ T cells isolated from peripheral blood mononuclear cells and gastric cancer tissues was evaluated by multicolor flow cytometry. PD-1 and PD-L1 were expressed in 30.0 and 60.5% of the gastric cancer tissues, respectively. The expression of PD-L1 was higher i

SUBMITTER: Kim JH 

PROVIDER: S-EPMC6676655 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature