Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury.

ABSTRACT: In chronic phase of spinal cord injury, functional recovery is more untreatable compared with early intervention in acute phase of spinal cord injury. In the last decade, several combination therapies successfully improved motor dysfunction in chronic spinal cord injury. However, their effectiveness is not sufficient. We previously found a new effective compound for spinal cord injury, matrine, which induced axonal growth and functional recovery in acute spinal cord injury mice via direct activation of extracellular heat shock protein 90. Although our previous study clarified that matrine was an activator of extracellular heat shock protein 90, the potential of matrine for spinal cord injury in chronic phase has not been sufficiently evaluated. Thus, this study aimed to investigate whether

SUBMITTER: Tanabe N 

PROVIDER: S-EPMC6676875 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature