Paired associative stimulation improves synaptic plasticity and functional outcomes after cerebral ischemia.

ABSTRACT: Paired associative stimulation is a relatively new non-invasive brain stimulation technique that combines transcranial magnetic stimulation and peripheral nerve stimulation. The effects of paired associative stimulation on the excitability of the cerebral cortex can vary according to the time interval between the transcranial magnetic stimulation and peripheral nerve stimulation. We established a model of cerebral ischemia in rats via transient middle cerebral artery occlusion. We administered paired associative stimulation with a frequency of 0.05 Hz 90 times over 4 weeks. We then evaluated spatial learning and memory using the Morris water maze. Changes in the cerebral ultra-structure and synaptic plasticity were assessed via transmission electron microscopy and a 64-channel multi-electr

SUBMITTER: Hu Y 

PROVIDER: S-EPMC6676880 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature