MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis.

ABSTRACT:

Objective

To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain injury.

Data sources

Key terms were "stroke", "brain diseases", "brain injuries", "brain hemorrhage, traumatic", "acute brain injury", "dizocilpine maleate", "dizocilpine", "MK-801", "MK801", "rat", "rats", "rattus" and "murine". PubMed, Cochrane library, EMBASE, the China National Knowledge Infrastructure, WanFang database, the VIP Journal Integration Platform (VJIP) and SinoMed databases were searched from their inception dates to March 2018.

Data selection

Studies were selected if they reported the effects of MK-801 in experimental acute brain injury. Two investigators independently conducted literature screening, data extraction, and methodological

SUBMITTER: Yi NX 

PROVIDER: S-EPMC6676887 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature