Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma.

ABSTRACT:

Purpose

Glaucoma is a complex disease with major risk factors including advancing age and increased intraocular pressure (IOP). Dissecting these earliest events will likely identify new avenues for therapeutics. Previously, we performed transcriptional profiling in DBA/2J (D2) mice, a widely used mouse model relevant to glaucoma. Here, we use these data to identify and test regulators of early gene expression changes in DBA/2J glaucoma.

Methods

Upstream regulator analysis (URA) in Ingenuity Pathway Analysis was performed to identify potential master regulators of differentially expressed genes. The function of one putative regulator, mesenchyme homeobox 2 (Meox2), was tested using a combination of genetic, biochemical, and immunofluorescence approaches.

Results

URA id

SUBMITTER: Buchanan RA 

PROVIDER: S-EPMC6676925 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature