Human Cortical Thickness Organized into Genetically-determined Communities across Spatial Resolutions.

ABSTRACT: The cerebral cortex may be organized into anatomical genetic modules, communities of brain regions with shared genetic influences via pleiotropy. Such modules could represent novel phenotypes amenable to large-scale gene discovery. This modular structure was investigated with network analysis of in vivo MRI of extended pedigrees, revealing a "multiscale" structure where smaller and larger modules exist simultaneously and in partially overlapping fashion across spatial scales, in contrast to prior work suggesting a specific number of cortical thickness modules. Inter-regional genetic correlations, gene co-expression patterns and computational models indicate that two simple organizational principles account for a large proportion of the apparent complexity in the network of genetic correlat

SUBMITTER: Alexander-Bloch AF 

PROVIDER: S-EPMC6676978 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature