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Enhanced three-photon activity triggered by the AIE behaviour of a novel terpyridine-based Zn(ii) complex bearing a thiophene bridge.

ABSTRACT: Multiphoton bioimaging benefits from good penetration of tissue, low phototoxicity and high resolution. Hence, development of efficient multiphoton imaging agents is highly desirable but remains challenging. Herein, a novel terpyridine-based Zn(ii) complex bearing a thiophene bridge was designed rationally and fabricated. Thanks to its aggregation-induced emission (AIE), DZ1 emitted bright yellow-green fluorescence (λ _em = 575 nm) under physiological conditions. The three-photon spectral changes of DZ1 when binding with RNA unambiguously reflected its RNA-specific targeting behaviour, resulting in twofold enhancement in three-photon action cross-sections located at the second near-infrared window (1700 nm).

SUBMITTER: Feng Z

PROVIDER: S-EPMC6677111 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Enhanced three-photon activity triggered by the AIE behaviour of a novel terpyridine-based Zn(ii) complex bearing a thiophene bridge.

Feng Zhihui Z Li Dandan D Zhang Mingzhu M Shao Tao T Shen Yu Y Tian Xiaohe X Zhang Qiong Q Li Shengli S Wu Jieying J Tian Yupeng Y

Chemical science 20190611 30

Multiphoton bioimaging benefits from good penetration of tissue, low phototoxicity and high resolution. Hence, development of efficient multiphoton imaging agents is highly desirable but remains challenging. Herein, a novel terpyridine-based Zn(ii) complex bearing a thiophene bridge was designed rationally and fabricated. Thanks to its aggregation-induced emission (AIE), DZ1 emitted bright yellow-green fluorescence (λ em = 575 nm) under physiological conditions. The thre ...[more]

PMID: 31588291

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