Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication.

ABSTRACT: Decision making relies on dynamic interactions of distributed, primarily frontal brain regions. Extensive evidence from functional magnetic resonance imaging (fMRI) studies indicates that the anterior cingulate (ACC) and the lateral prefrontal cortices (latPFC) are essential nodes subserving cognitive control. However, because of its limited temporal resolution, fMRI cannot accurately reflect the timing and nature of their presumed interplay. The present study combines distributed source modeling of the temporally precise magnetoencephalography (MEG) signal with structural MRI in the form of "brain movies" to: (1) estimate the cortical areas involved in cognitive control ("where"), (2) characterize their temporal sequence ("when"), and (3) quantify the oscillatory dynamics of their neural

SUBMITTER: Marinkovic K 

PROVIDER: S-EPMC6677147 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature